Peptipedia
Anti-AgingNot FDA ApprovedClinical Trials

Glutathione

Also known as L-Glutathione, GSH, Reduced Glutathione, γ-L-glutamyl-L-cysteinyl-glycine

The body's master antioxidant - a tripeptide composed of glutamate, cysteine, and glycine.

GRAS Status (Generally Recognized As Safe) - Extensive Human Research
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

500-1000 mg daily (oral or liposomal)

Frequency

1-2x daily

Duration

Ongoing or 4-12 week courses

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 500-1000 mg daily (oral or liposomal) via Oral, liposomal, IV, or subcutaneous, 1-2x daily. Dose range: 250-2000 mg daily depending on form. Duration: Ongoing or 4-12 week courses.

Timing & Administration

Administer via Oral, liposomal, IV, or subcutaneous. Frequency: 1-2x daily.

Mechanism of Action

Directly neutralizes free radicals including superoxide, hydroxyl radicals, and nitric oxide. Regenerates vitamins C and E, detoxifies peroxides through glutathione peroxidase enzymes, and supports Phase II liver detoxification.

Research Summary

Evidence level: clinical trials. Clinical status: GRAS Status (Generally Recognized As Safe) - Extensive Human Research.

Side Effects & Safety

Important Warnings

  • FDA contamination warnings for compounded forms
  • Inhaled form may worsen asthma.
Bloating
mild cramping
gas
loose stools (oral)
injection site reactions (IV)
rare hepatotoxicity (IV)
flushing

References

No references available.

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