Peptipedia
HormonalFDA ApprovedFDA Approved

Gonadorelin

Also known as GnRH, LHRH, Factrel

A synthetic version of gonadotropin-releasing hormone used diagnostically and therapeutically for reproductive conditions.

FDA Approved - Diagnostic and therapeutic uses
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

100-500 mcg

Frequency

2-3x weekly

Duration

Single dose (diagnostic) or ongoing (therapeutic)

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 100-500 mcg via IV, subcutaneous, or pulsatile pump, 2-3x weekly. Dose range: 50-500 mcg per dose. Duration: Single dose (diagnostic) or ongoing (therapeutic).

Timing & Administration

Administer via IV, subcutaneous, or pulsatile pump. Frequency: 2-3x weekly.

Mechanism of Action

Stimulates the pituitary to release LH and FSH. Pulsatile administration supports natural hormone production, while continuous administration causes desensitization and hormone suppression.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Diagnostic and therapeutic uses.

Side Effects & Safety

Important Warnings

  • May worsen hormone-dependent cancers
Injection site reactions
headache
flushing
nausea
risk of multiple births
long-term bone density decrease

References

No references available.

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