Peptipedia
ImmunePreclinicalAnimal Studies

KPV

Also known as Lys-Pro-Val, Alpha-MSH fragment

A tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH). Known for potent anti-inflammatory effects, particularly in the gut.

Preclinical - Research ongoing
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

200-500 mcg daily

Frequency

1-2x daily

Duration

4-8 weeks typical

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 200-500 mcg daily via Subcutaneous injection or oral (capsules), 1-2x daily. Dose range: 100-1000 mcg daily. Duration: 4-8 weeks typical.

Timing & Administration

Administer via Subcutaneous injection or oral (capsules). Frequency: 1-2x daily.

Mechanism of Action

Retains the anti-inflammatory properties of α-MSH without melanocortin receptor activation. Inhibits inflammatory pathways including NF-κB, reduces pro-inflammatory cytokines, and has antimicrobial properties.

Research Summary

Evidence level: animal studies. Clinical status: Preclinical - Research ongoing.

Side Effects & Safety

Important Warnings

  • Does NOT cause immunosuppression
  • Contraindicated with cancer history.
Injection site reactions
mild flu-like symptoms
mild GI effects
potential histamine release

References

No references available.

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