Peptipedia
HormonalFDA ApprovedFDA Approved

Calcitonin

Also known as Miacalcin, Fortical, Salmon Calcitonin

A thyroid hormone that inhibits bone resorption. Salmon calcitonin demonstrates 40-50x greater potency than human forms.

FDA Approved - Osteoporosis and Paget's disease
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

200 IU intranasal daily or 100 IU SC/IM daily

Frequency

Daily

Duration

Long-term for osteoporosis

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 200 IU intranasal daily or 100 IU SC/IM daily via Intranasal spray or injection, Daily. Dose range: 100-200 IU per dose. Duration: Long-term for osteoporosis.

Timing & Administration

Administer via Intranasal spray or injection. Frequency: Daily.

Mechanism of Action

Binds to osteoclast receptors, inhibiting bone breakdown. Reduces renal calcium reabsorption and has analgesic effects on bone pain.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Osteoporosis and Paget's disease.

Side Effects & Safety

Important Warnings

  • Meta-analysis finding of increased malignancy risk
Nausea (10%)
injection site reactions
facial flushing
nasal symptoms (spray)
hypocalcemia
anaphylaxis (rare)
increased malignancy risk (meta-analysis)

References

No references available.

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