Peptipedia
HormonalFDA ApprovedFDA Approved

Cosyntropin

Also known as Cortrosyn, ACTH 1-24, Tetracosactide

A synthetic fragment of ACTH used to diagnose adrenal insufficiency. The standard test for evaluating adrenal function. Contains the first 24 amino acids of ACTH.

FDA Approved - Diagnostic use
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

250 mcg IV/IM (standard) or 1 mcg IV (low-dose)

Frequency

Single diagnostic dose

Duration

Single diagnostic dose

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 250 mcg IV/IM (standard) or 1 mcg IV (low-dose) via IV or intramuscular, Single diagnostic dose. Dose range: 1-250 mcg per dose. Duration: Single diagnostic dose.

Timing & Administration

Administer via IV or intramuscular. Frequency: Single diagnostic dose.

Mechanism of Action

Contains the first 24 amino acids of ACTH, which is all that is needed for biological activity. Stimulates cortisol release from the adrenal glands.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Diagnostic use.

Side Effects & Safety

Important Warnings

  • Hypersensitivity reactions common
Hypersensitivity reactions (common)
injection site reactions
bradycardia or tachycardia
blood pressure changes
headache

References

No references available.

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