Peptipedia
HormonalFDA ApprovedFDA Approved

Eptifibatide

Also known as Integrilin

A cyclic peptide that inhibits platelet aggregation. Used during coronary interventions to prevent clot formation. Derived from a protein in pygmy rattlesnake venom.

FDA Approved - Acute coronary syndrome and PCI
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

180 mcg/kg IV bolus; 2 mcg/kg/min infusion

Frequency

IV bolus + continuous infusion up to 72 hours

Duration

Up to 72 hours

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 180 mcg/kg IV bolus; 2 mcg/kg/min infusion via IV bolus and infusion, IV bolus + continuous infusion up to 72 hours. Dose range: 180 mcg/kg bolus; 2 mcg/kg/min infusion. Duration: Up to 72 hours.

Timing & Administration

Administer via IV bolus and infusion. Frequency: IV bolus + continuous infusion up to 72 hours.

Mechanism of Action

RGD-mimetic that blocks the glycoprotein IIb/IIIa receptor on platelets, preventing fibrinogen binding and platelet aggregation.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Acute coronary syndrome and PCI.

Side Effects & Safety

Important Warnings

  • High-risk medication per ISMP
Bleeding (28% - most common)
major bleeding (3-10%)
hypotension
thrombocytopenia
allergic reactions

References

No references available.

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