Peptipedia
HormonalFDA ApprovedFDA Approved

Macimorelin

Also known as Macrilen, AEZS-130

An oral ghrelin mimetic for diagnosing adult growth hormone deficiency. The first FDA-approved oral GH stimulation test. 92% concordance with insulin tolerance testing.

FDA Approved - Diagnostic for Adult Growth Hormone Deficiency
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

0.5 mg/kg oral single dose

Frequency

Single diagnostic test

Duration

Single diagnostic test

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 0.5 mg/kg oral single dose via Oral solution, fasting, Single diagnostic test. Dose range: 0.5 mg/kg per test. Duration: Single diagnostic test.

Timing & Administration

Administer via Oral solution, fasting. Frequency: Single diagnostic test.

Mechanism of Action

Activates ghrelin receptors (GHSR-1a), stimulating GH release from the pituitary.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Diagnostic for Adult Growth Hormone Deficiency.

Side Effects & Safety

Important Warnings

  • QT prolongation risk
Taste changes (dysgeusia)
dizziness
headache
nausea
QT prolongation

References

No references available.

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