Peptipedia
HormonalPreclinicalAnimal Studies

MOTS-c

Also known as Mitochondrial ORF of the 12S rRNA type-c

A mitochondria-derived peptide that regulates metabolic homeostasis, discovered in 2015 and studied for insulin sensitivity, exercise capacity, and aging effects.

Preclinical - Early human studies beginning
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

5-10 mg weekly

Frequency

1-3x weekly

Duration

Variable by protocol

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 5-10 mg weekly via Subcutaneous injection, 1-3x weekly. Dose range: 5-15 mg per week. Duration: Variable by protocol.

Timing & Administration

Administer via Subcutaneous injection. Frequency: 1-3x weekly.

Mechanism of Action

Acts as a mitokine encoded by mitochondrial DNA, communicating mitochondrial status to the rest of the body. Activates AMPK, improves glucose uptake, and enhances fatty acid oxidation.

Research Summary

Evidence level: animal studies. Clinical status: Preclinical - Early human studies beginning.

Side Effects & Safety

Important Warnings

  • Potential metformin interactions
  • Long-term effects unknown.
Injection site reactions
palpitations
nausea
bloating
fatigue
potential histamine release

References

No references available.

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