Peptipedia
HormonalFDA ApprovedFDA Approved

Teriparatide

Also known as Forteo, PTH 1-34

A recombinant parathyroid hormone fragment that stimulates bone formation. Demonstrated 65% reduction in vertebral fractures in clinical trials.

FDA Approved - Osteoporosis
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

20 mcg daily

Frequency

Once daily

Duration

Maximum 2 years (lifetime limit)

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 20 mcg daily via Subcutaneous injection daily, Once daily. Dose range: 20 mcg daily. Duration: Maximum 2 years (lifetime limit).

Timing & Administration

Administer via Subcutaneous injection daily. Frequency: Once daily.

Mechanism of Action

Intermittent dosing stimulates osteoblasts more than osteoclasts, resulting in net bone formation - an anabolic effect differing from antiresorptive osteoporosis medications.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Osteoporosis.

Side Effects & Safety

Important Warnings

  • Boxed warning: osteosarcoma risk
  • Maximum 2-year lifetime treatment.
Joint pain (10%)
nausea
headache
dizziness
leg cramps
injection site reactions
orthostatic hypotension
hypercalcemia

References

No references available.

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